Search results for "Field cancerization"

showing 4 items of 4 documents

Immunoprofiles and DNA methylation of inflammatory marker genes in ulcerative colitis-associated colorectal tumorigenesis

2021

Immunological and epigenetic changes are interconnected and contribute to tumorigenesis. We determined the immunoprofiles and promoter methylation of inflammation-related genes for colitis-associated colorectal carcinomas (CA-CRC). The results were compared with Lynch syndrome (LS)-associated colorectal tumors, which are characterized by an active immune environment through inherited mismatch repair defects. CA-CRCs (n = 31) were immunohistochemically evaluated for immune cell scores (ICSs) and PDCD1 and CD274 expression. Seven inflammation-associated genes (CD274, NTSR1, PPARG, PTGS2, PYCARD, SOCS1, and SOCS2), the repair gene MGMT, and eight standard marker genes for the CpG Island Methyl…

MaleCarcinogenesismedicine.disease_causeBiochemistry0302 clinical medicineIntestinal MucosaDNA Modification Methylases0303 health sciencesMUCOSADNA methylationtulehdusinflammation-associated genesPYCARDMethylationMiddle AgedLynch syndromeQR1-502EPIGENETICS3. Good healthDNA-metylaatioGene Expression Regulation NeoplasticPhenotypecolon cancerepigenetiikka030220 oncology & carcinogenesisimmuunivasteDNA methylationFemaleColorectal NeoplasmsCANCERSINSTABILITYsuolistosyövätBiology3121 Internal medicineMicrobiologyArticle03 medical and health sciencesmedicineHumansEpigeneticsLynchin oireyhtymäMolecular Biologyneoplasms030304 developmental biologypaksusuolisyöpäulcerative colitisInflammationCpG Island Methylator PhenotypeTumor Suppressor Proteinshaavainen koliittimedicine.disease3126 Surgery anesthesiology intensive care radiologydigestive system diseasesDNA Repair EnzymesLynch syndrome3121 General medicine internal medicine and other clinical medicineMutationimmune cell scoreCancer research1182 Biochemistry cell and molecular biologyColitis UlcerativeCpG IslandsField cancerizationCarcinogenesisBiomarkers
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Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma

2014

The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed…

MalePathologyNitric Oxide Synthase Type IImedicine.disease_causechemistry.chemical_compoundField cancerizationMedicineNitriteMouth neoplasmAged 80 and overbiologymedicine.diagnostic_testCarcinoma oral de células escamosasNitric oxide synthase 2Patología//purl.org/becyt/ford/3.1 [https]Middle Aged:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludMedicina BásicaOral squamous cell carcinomaUNESCO::CIENCIAS MÉDICASCarcinoma Squamous CellImmunohistochemistryFemaleMouth Neoplasms//purl.org/becyt/ford/3 [https]Adultmedicine.medical_specialtyCIENCIAS MÉDICAS Y DE LA SALUDOdontologíaBiopsyparasitic diseasesCarcinomaHumansNitric Oxide Synthase 2 (NOS2)Cancerización de campoGeneral DentistryAgedMarcadores de malignidadOral Medicine and Pathologybusiness.industryResearchmedicine.diseasestomatognathic diseasesCross-Sectional StudiesOtorhinolaryngologychemistrybiology.proteinSurgeryField cancerizationbusinessCarcinogenesisMalignity markers
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A CASE REPORT OF 2 METACHRONOUS ORAL SQUAMOUS CELL CARCINOMAS AND 1 RECURRENCE IN 7 YEARS

2022

ORAL SQUAMOUS CELL CARCINOMAS FIELD CANCERIZATION SYNCHRONOUS TUMOR METACHRONOUS TUMOR
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Evidence of field cancerization of oral squamous cell carcinoma: a case report

2014

Objectives. From 1953 (1) the term “field cancerization” has been used to describe an “increased risk of cancer de- velopment in the entire upper aerodigestive tract due to multiple genetic abnormalities in the whole region after pro- longed exposure to carcinogen” (2). This phenomenon implies the occurrence of multiple primary tumors/potentially malignant disorders as results of cell-molecular aberrations in different independent sites (polyclonal theory) or from the same site through widespread expansion or later spread across the mucosa (monoclonal theory). Case report. A 63-year-old female patient referred in June of 2014 for exophytic/ulcerative lesion in the hard palate. At the same t…

Settore MED/28 - Malattie OdontostomatologicheSettore MED/50 - Scienze Tecniche Mediche Applicatefield cancerization oral squamous cell carcinoma cancer developmentSettore MED/29 - Chirurgia Maxillofacciale
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